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Reagent Storage Chest
I know of 46 creatures that drop Tough. There could be more, I don't have the scoop on ALL the bosses out there yet. I been trying to get Digby to do my work for me - uh, I mean HELP me, but I haven't had much luck yet.

Alicane Swiftarrow Fireglobe Theatre, Wizard City
Bellows Counterweight West, Marleybone
Clanker Katzenstein's Lab, Marleybone
Crazed Forest Spirit Ancient Burial Grounds, MooShu
Cursed Ronin Ancient Burial Grounds, MooShu
Cyn De Lobster (Tier 5)Baddle of the Bands (Tier 5)
Dead Beets (Tier 5) Tanglewood Terror (Tier 5)
Emil SoftPaw Telegraph Box (Marleybone), Marleybone
Fleshrender Vigrid Roughland, Grizzleheim
Foulgaze Sapphyra's Tower, Wizard City
General Akilles Akilles' Tower, Wizard City
Gloom Fairy Ancient Burial Grounds, MooShu
Grimsnes BurntBlackTelegraph Box (Wizard City), Wizard City
Haunted Minion Dark Cave, Wizard City
Imitsu Defouler Kishibe Village, MooShu
Infected Villager Kishibe Village, MooShu
Jacques the Scratcher (Rank 5) Knight's Court, Marleybone
Jitterbug , Marleybone
Kestrel BlackstormMysterious Tower (Wizard City), Wizard City
Kraken Triton Avenue, Wizard City

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