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Reagent Storage Chest
I know of 16 creatures that drop Plague. There could be more, I don't have the scoop on ALL the bosses out there yet. I been trying to get Scarlet to do my work for me - uh, I mean HELP me, but I haven't had much luck yet.

NameWorld
Akhtang WormCrawlCastle Darkmoor, Wizard City
Bane WyrmCaliburn, Avalon
Caquix Nine ShadowsMangrove Marsh, Azteca
Count Bela BlackSleepCastle Darkmoor, Wizard City
Doctor JackallBarkingham Palace, Marleybone
Drowned KnightDeepwater, Avalon
LoremasterThe Atheneum, Dragonspyre
Morag BloodtineCaer Lyon, Avalon
Murat GreyeyesElephant Graveyard, Zafaria
Noxious Gas GolemBarkingham Palace, Marleybone
PendragonOuter Yard, Avalon
Shane von ShaneCastle Darkmoor, Wizard City
Shane von Shane (Star)Castle Darkmoor, Wizard City
Sir BlackwaterCastle Darkmoor, Wizard City
Yevgeny NightCreeperCastle Darkmoor, Wizard City
Young MorgantheCrystal Caves, Avalon