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Reagent Storage Chest
I know of 14 creatures that drop Plague. There could be more, I don't have the scoop on ALL the bosses out there yet. I been trying to get Esmee to do my work for me - uh, I mean HELP me, but I haven't had much luck yet.

Akhtang WormCrawlUpper Halls, Wizard City
Bane Wyrm Lair of the Bane Wyrm, Avalon
Count Bela BlackSleep Castle Darkmoor, Wizard City
Doctor Jackall Royal Airship, Marleybone
Drowned Knight Deepwater, Avalon
Loremaster Loremaster's Chamber, Dragonspyre
Morag Bloodtine Morag Bloodtine's House, Avalon
Noxious Gas Golem Main Hall, Marleybone
Pendragon Outer Yard, Avalon
Shane von Shane Upper Halls, Wizard City
Shane von Shane (Star) Graveyard, Wizard City
Sir Blackwater Castle Darkmoor, Wizard City
Yevgeny NightCreeper Graveyard, Wizard City
Young Morganthe Crystal Caves, Avalon