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Reagent Storage Chest
I know of 6 creatures that drop Guidance. There could be more, I don't have the scoop on ALL the bosses out there yet. I been trying to get Esmee to do my work for me - uh, I mean HELP me, but I haven't had much luck yet.

NameLocation
Chief WhipBarkingham Palace, Marleybone
Doctor JackallBarkingham Palace, Marleybone
Keela White TalonThe Wild, Avalon
Mord RoughshodCaer Lyon, Avalon
Noxious Gas GolemBarkingham Palace, Marleybone
Rags O'LearyDigmoore Station, Marleybone